Drug-induced thrombocytopenia secondary to antibiotic exposure is a rare complication more commonly associated with other medications.In this review, we present a case of antibiotic-induced thrombocytopenia and discuss the clinical picture and approach to identifying the complication.With accles and shelvoke increasing use of antibiotics that may be associated with acure face lotion drug-induced thrombocytopenia in perioperative prophylaxis protocols, surgeons need to be cognizant of this cause of thrombocytopenia in the postoperative patient.A delay in recognition and discontinuation of the offending agent can result in significant complications secondary to bleeding and superfluous testing.